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| A L. Bossolani-Martins; F C. Rodrigues-Lisoni; M L. Nogueira; A Barbosa-Gonçalves; E H. Tajara; A C. Fett-Conte. |
| Autism spectrum disorders are a group of neurodevelopmental disorders with a complex and heterogeneous etiology. Studies have shown that genetic factors play an important role in the aetiology of these diseases. Recently, de novo mutations, frameshifts and deletions have been described in the SHANK3 gene, also known as ProSAP2 gene, which encodes a synaptic scaffolding protein. All the participants of this study had normal karyotypes and underwent screening for Fragile-X syndrome. Subsequently, they were analyzed by direct sequencing of different points of exons 8 and 22 of the SHANK3 gene. None of the study participants presented with changes in these regions. These findings may be due to the fact that mutations, deletions and duplications of the SHANK3... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4200/version/1 |
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| A. Patrice Seyed. |
| This paper examines the primitive relations (dependence, quality, and constitution) of the BFO and DOLCE upper ontologies, employed in developing domain ontologies of the biomedical sciences. The strengths in both upper ontologies are examined, which sets a framework for developing a common upper ontology that utilizes the assets of both. |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3481/version/1 |
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| Aaron G. Filler. |
| A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the 115 years between the discovery of the X-ray and the advent of high resolution diffusion based functional MRI. The story of the progress in human terms, with its battles for priorities, forgotten advances, competing claims, public battles for Nobel Prizes, and patent priority litigations bring alive the human drama of this remarkable collective achievement in computed medical imaging. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3267/version/5 |
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| Aaron G. Filler. |
| A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the 115 years between the discovery of the X-ray and the advent of high resolution diffusion based functional MRI. The story of the progress in human terms, with its battles for priorities, forgotten advances, competing claims, public battles for Nobel Prizes, and patent priority litigations bring alive the human drama of this remarkable collective achievement in computed medical imaging. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3267/version/3 |
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| Aaron G. Filler. |
| Objective – Methods were invented that made it possible to image peripheral nerves in the body and to image neural tracts in the brain. Over a 15 year period, these techniques – MR Neurography and Diffusion Tensor Imaging – were then deployed in the clinical and research community and applied to about 50,000 patients. Within this group, about 5,000 patients having MR Neurography were carefully tracked on a prospective basis.

Method – In the study group a uniform imaging methodology was applied and all images were reviewed and registered by referral source, clinical indication, efficacy of imaging and quality. Various classes of image findings were identified and subjected to a... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2877/version/1 |
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| Aaron G. Filler. |
| A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the 115 years between the discovery of the X-ray and the advent of high resolution diffusion based functional MRI. The story of the progress in human terms, with its battles for priorities, forgotten advances, competing claims, public battles for Nobel Prizes, and patent priority litigations bring alive the human drama of this remarkable collective achievement in computed medical imaging. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3267/version/1 |
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| Aaron G. Filler. |
| Objective – Methods were invented that made it possible to image peripheral nerves in the body and to image neural tracts in the brain. Over a 15 year period, these techniques – MR Neurography and Diffusion Tensor Imaging – were then deployed in the clinical and research community and applied to about 50,000 patients. Within this group, about 5,000 patients having MR Neurography were carefully tracked on a prospective basis.

Method – In the study group a uniform imaging methodology was applied and all images were reviewed and registered by referral source, clinical indication, efficacy of imaging and quality. Various classes of image findings were identified and subjected to a... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2877/version/2 |
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| Aaron G. Filler. |
| *Objective:* Methods were invented that made it possible to image peripheral nerves in the body and to image neural tracts in the brain. Over a 15 year period, these techniques – MR Neurography and Diffusion Tensor Imaging – were then deployed in the clinical and research community and applied to about 50,000 patients. Within this group, about 5,000 patients having MR Neurography were carefully tracked on a prospective basis.

*Method:* In the study group a uniform imaging methodology was applied and all images were reviewed and registered by referral source, clinical indication, efficacy of imaging and quality. Various classes of image findings were identified and subjected to a variety of small... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1932/version/2 |
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| Aaron G. Filler. |
| Objective – Methods were invented that made it possible to image peripheral nerves in the body and to image neural tracts in the brain. Over a 15 year period, these techniques – MR Neurography and Diffusion Tensor Imaging – were then deployed in the clinical and research community and applied to about 50,000 patients. Within this group, about 5,000 patients having MR Neurography were carefully tracked on a prospective basis.

Method – In the study group a uniform imaging methodology was applied and all images were reviewed and registered by referral source, clinical indication, efficacy of imaging and quality. Various classes of image findings were identified and subjected to a... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1932/version/1 |
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| Aaron G. Filler. |
| A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the 115 years between the discovery of the X-ray and the advent of high resolution diffusion based functional MRI. The story of the progress in human terms, with its battles for priorities, forgotten advances, competing claims, public battles for Nobel Prizes, and patent priority litigations bring alive the human drama of this remarkable collective achievement in computed medical imaging. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3267/version/2 |
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| Aaron G. Filler. |
| A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the 115 years between the discovery of the X-ray and the advent of high resolution diffusion based functional MRI. The story of the progress in human terms, with its battles for priorities, forgotten advances, competing claims, public battles for Nobel Prizes, and patent priority litigations bring alive the human drama of this remarkable collective achievement in computed medical imaging. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3267/version/4 |
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| Aaron W. Baum; Tadeusz Patzek; Martin Bender; Steve Renich; Wes Jackson. |
| An understanding of agriculture's energy, material, and labor requirements is essential for achieving economic and ecological sustainability, and for assessing the effectiveness of relevant policy decisions (biofuel subsidies, regulations, labeling, etc.). Previous studies of energy, materials, and labor use in farming have been based on either unverified voluntary reporting or test plots, rather than on the high-resolution measurements of mass and energy flows. Here we present a recursive analysis of 1.25 million data points describing in unprecedented detail the resource transactions on a 60 ha farm functioning for over 6 years. This analysis highlights the importance of accounting for all types of materials, as well as capital equipment,... |
| Tipo: Manuscript |
Palavras-chave: Ecology; Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4291/version/1 |
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| Abdelghani Chakhchar; Abderrahim Ferradous; Mouna Lamaoui; Said Wahbi; Cherkaoui El Modafar. |
| _Argania spinosa_ L. Skell, a tree endemic of Morocco, grows in semiarid and arid areas. Biochemical response to drought in four ecotypes of the _A. spinosa_ was compared. Choice of ecotypes was based on evident differences in geographical features in south-west Morocco: two coastal ecotypes (Essaouira and Agadir) and two paralittorale ecotypes (Aoulouz and Lakhssas). Lipid peroxidation (malonyldialdehyde (MDA)), content of endogenous hydrogen peroxide (H2O2) and antioxidant enzyme system (Catalase (CAT), Ascorbate peroxidase (APX), Total peroxidase (POD) and Polyphenoloxidase (PPO) were measured in control (100% relative humidity (RH) at field capacity (FC)) and water-stressed plants (50 and 25% RH at FC). For all ecotypes, drought stress significantly... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Plant Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6189/version/1 |
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| Abhay Krishna. |
| Compared to other natural sciences ecological sciences has always been about seeing the bigger picture. The realization that local actions can have global impact has been the hallmark of ecological research. This integrative view is getting more and more accepted now with the recognition that whole is definitely more then sum of its parts. Advancement in computer sciences has now made it possible to comprehend the complexity arising from an integrative approach. This has given rise to a field interfacing computer science and ecological sciences called Ecoinformatics. The other popular parallel and more mature field is bioinformatics or computational biology. The presentation will take the audience on an Ecoinformatics tour touching on present status of... |
| Tipo: Presentation |
Palavras-chave: Ecology; Bioinformatics; Earth & Environment. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2018/version/1 |
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| Abhay Krishna. |
| In a fascinating tussle of perspectives in Volume 6 and issue no 3 of april 2008 Frontiers in Ecology and Evolution, Martin A Nuñez and Gregory M Crustinger enlist ways to brace up with the recent literature. They advocate that PhD students should choose a well studied system to have better chances of success. On the other side of this fascinating tussle Daniel Simberloff and Nathan J Sanders agree with there enthusiastic case and approaches for bracing up with the recent literature. However, they disagree with the play safe strategy of start-ups in ecology and evolution.

For me this tussle of perspectives is really fascinating. It underlines the story of our times. In the times of information explosion, should... |
| Tipo: Manuscript |
Palavras-chave: Ecology; Bioinformatics; Earth & Environment. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1959/version/1 |
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| Abhay Krishna; Ajit Narayanan. |
| Genome-scale molecular networks, including gene pathways, gene regulatory networks and protein interactions, are central to the investigation of the nascent disciplines of systems biology and bio-complexity. Dissecting these genome-scale molecular networks in its all-possible manifestations is paramount in our quest for a genotype-input phenotype-output application which will also take environment-genome interactions into account.

Machine learning approaches are now increasingly being used for reverse engineering such networks. Our work stresses the importance of a system approach in biological research and how artificial neural networks are at the forefront of Artificial Intelligence techniques that are increasingly... |
| Tipo: Presentation |
Palavras-chave: Ecology; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2003/version/1 |
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| Abhay Sharma. |
| Transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics has recently been discovered using a Drosophila systems model. In this novel mode of inheritance, transcriptomic alteration induced by the neuroactive drug pentylenetetrazole (PTZ) has been found to leak to future generations. Here, the available microarray gene expression data pertaining to CNS and/or testis of exposed F0 and the resulting F1 and F2 generations has been pooled and analyzed in an unbiased manner at four levels, namely, biological processes and pathways, protein interactome networks, miRNA-targets, and microarray expression profile similarities. Enrichment for processes related to translation, energy metabolism, cell proliferation, cell... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3312/version/1 |
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| Registros recuperados: 3.453 | |
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